Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

Moin, S. M., Boyington, J. C., Boyoglu-Barnum, S., Gillespie, R. A., Cerutti, G., Cheung, C. S.-F., Cagigi, A., Gallagher, J. R., Brand, J., Prabhakaran, M., Tsybovsky, Y., Stephens, T., Fisher, B. E., Creanga, A., Ataca, S., Rawi, R., Corbett, K. S., Crank, M. C., Karlsson Hedestam, G. B., … Kanekiyo, M. (2022). Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses. Immunity, 55(12), 2405-2418.e7. https://doi.org/10.1016/j.immuni.2022.10.015
Authors:
Syed M Moin
Jeffrey C Boyington
Seyhan Boyoglu-Barnum
Rebecca A Gillespie
Gabriele Cerutti
Crystal Sao-Fong Cheung
Alberto Cagigi
John R Gallagher
Joshua Brand
Madhu Prabhakaran
Yaroslav Tsybovsky
Tyler Stephens
Brian E Fisher
Adrian Creanga
Sila Ataca
Reda Rawi
Kizzmekia S Corbett
Michelle C Crank
Gunilla B Karlsson Hedestam
Jason Gorman
Adrian B McDermott
Audray K Harris
Tongqing Zhou
Peter D Kwong
Lawrence Shapiro
John R Mascola
Barney S Graham
Masaru Kanekiyo
Affiliated Authors:
Gabriele Cerutti
Kizzmekia S Corbett
Lawrence Shapiro
Columbia Affiliation:
Subjects:
Influenza Vaccines (MeSH)
Influenza A Virus, H5N1 Subtype (MeSH)
Orthomyxoviridae Infections (MeSH)
Influenza A Virus, H7N9 Subtype (MeSH)
Influenza, Human (MeSH)
Author Keywords:
ha stalk
ha stem
bnab
cryo-em
ferritin
influenza
nanoparticle
nonhuman primate
pandemic preparedness
vaccine
elink
Publication Type:
Article
Unique ID:
10.1016/j.immuni.2022.10.015
PMID:
36356572
DOI:
10.1016/j.immuni.2022.10.015
Journal:
Immunity
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: