RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

Spence, H., Waldron, F. M., Saleeb, R. S., Brown, A.-L., Rifai, O. M., Gilodi, M., Read, F., Roberts, K., Milne, G., Wilkinson, D., O’Shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H., & Gregory, J. M. (2024). RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS. Acta Neuropathologica, 147(1). https://doi.org/10.1007/s00401-024-02705-1
Authors:
Holly Spence
Fergal M. Waldron
Fiona Read
Gillian Milne
Debbie Wilkinson
Jenna M. Gregory
Rebecca S. Saleeb
Judi O'Shaughnessy
Mathew H. Horrocks
Anna-Leigh Brown
Pietro Fratta
Olivia M. Rifai
Martina Gilodi
Gian Gaetano Tartaglia
Elsa Zacco
Kristine Roberts
Annalisa Pastore
Neil Shneider
Affiliated Authors:
Neil Shneider
Author Keywords:
tdp-43
loss-of-function
neuropathology
cryptic splicing
stathmin-2
rna aptamer
amyotrophic lateral sclerosis
cognition
Publication Type:
Article
Unique ID:
10.1007/s00401-024-02705-1
PMID:
Publication Date:
Data Source:
Web of Science

Record Created: