OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases

Sturm, G., Karan, K. R., Monzel, A. S., Santhanam, B., Taivassalo, T., Bris, C., Ware, S. A., Cross, M., Towheed, A., Higgins-Chen, A., McManus, M. J., Cardenas, A., Lin, J., Epel, E. S., Rahman, S., Vissing, J., Grassi, B., Levine, M., Horvath, S., … Picard, M. (2023). OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. Communications Biology, 6(1). https://doi.org/10.1038/s42003-022-04303-x
Authors:
Gabriel Sturm
Kalpita R. Karan
Anna S. Monzel
Balaji Santhanam
Tanja Taivassalo
Céline Bris
Sarah A. Ware
Marissa Cross
Atif Towheed
Albert Higgins-Chen
Meagan J. McManus
Andres Cardenas
Jue Lin
Elissa S. Epel
Shamima Rahman
John Vissing
Bruno Grassi
Morgan Levine
Steve Horvath
Ronald G. Haller
Guy Lenaers
Douglas C. Wallace
Marie-Pierre St-Onge
Saeed Tavazoie
Vincent Procaccio
Brett A. Kaufman
Erin L. Seifert
Michio Hirano
Martin Picard
Affiliated Authors:
Gabriel Sturm
Kalpita R. Karan
Anna S. Monzel
Balaji Santhanam
Marissa Cross
Atif Towheed
Marie-Pierre St-Onge
Saeed Tavazoie
Michio Hirano
Martin Picard
Columbia Affiliation:
Subjects:
Oxidative Phosphorylation (MeSH)
Mitochondrial Diseases (MeSH)
Mitochondrial Dynamics and Reactive Oxygen Species Regulation (OpenAlex Topic)
ATP Synthase Function and Regulation (OpenAlex Topic)
Role of Growth Factors in Health and Disease (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1038/s42003-022-04303-x
PMID:
36635485
DOI:
10.1038/s42003-022-04303-x
Journal:
Communications Biology
Publication Date:
Data Source:
Scopus
Source Link:
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